2023年

  1. Hamaguchi A, Fukuda H, Fujiwara K, Harada T, Fukushima K, Shuto S, Fujino H. Individual resolvin E family members work distinctly and in a coordinated manner in the resolution of inflammation. Prostaglandins Other Lipid Mediat. 168, 106759. (2023)
  2. Imanishi M, Inoue T, Fukushima K, Yamashita R, Nakayama R, Nojima M, Kondo K, Gomi Y, Tsunematsu H, Goto K, Miyamoto L, Funamoto M, Denda M, Ishizawa K, Otaka A, Fujino H, Ikeda Y, Tsuchiya K. CA9 and PRELID2; hypoxia-responsive potential therapeutic targets for pancreatic ductal adenocarcinoma as per bioinformatics analyses. J Pharmacol Sci., 153, 232-242. (2023)
  3. Horinouchi Y, Murashima Y, Yamada Y, Yoshioka S, Fukushima K, Kure T, Sasaki N, Imanishi M, Fujino H, Tsuchiya K, Shinomiya K, Ikeda Y. Pemafibrate inhibited renal dysfunction and fibrosis in a mouse model of adenine-induced chronic kidney disease. Life Sci., 15, 121590. (2023)
  4. Niimura T, Zamami Y, Miyata K, Mikami T, Asada M, Fukushima K, Yoshino M, Mitsuboshi S, Okada N, Hamano H, Sakurada T, Matsuoka-Ando R, Aizawa F, Yagi K, Goda M, Chuma M, Koyama T, Izawa-Ishizawa Y, Yanagawa H, Fujino H, Yamanishi Y, Ishizawa K. Characterization of Immune Checkpoint Inhibitor-Induced Myasthenia Gravis Using the US Food and Drug Administration Adverse Event Reporting System. J Clin Pharmacol., 63, 473-479. (2023)

2022年

  1. Fujino H*. Foreward, Current Topics - Recent Advances of GPCR Studies: An Old-Fashioned Perspective? Biol. Pharm. Bull., 45, 668. (2022)
  2. Fujino H*. The Biased Activities of Prostanoids and Their Receptors: Review and Beyond. Biol. Pharm. Bull., 45, 684-690. (2022)
  3. Kitagawa K, Hamaguchi A, Fukushima K, Nakano Y, Regan JW, Mashimo M, Fujino H. Down-regulation of the expression of cyclooxygenase-2 and prostaglandin E2 by interleukin-4 is mediated via a reduction in the expression of prostanoid EP4 receptors in HCA-7 human colon cancer cells. Eur J Pharmacol. 920, 174863. (2022)
  4. Yamagiwa N, Kobayashi H, Okabayashi H, Yasuda M, Fukushima K, Kawamura J, Kotoura S, Fujino H. Phosphatidylcholine-plasmalogen-oleic acid has protective effects against arachidonic acid-induced cytotoxicity. Biol Pharm Bull. (2022)
  5. Zamami Y, Niimura T, Kawashiri T, Goda M, Naito Y, Fukushima K, Ushio S, Aizawa F, Hamano H, Okada N, Yagi K, Miyata K, Takechi K, Chuma M, Koyama T, Kobayashi D, Shimazoe T, Fujino H, Izawa-Ishizawa Y, Ishizawa K. Identification of prophylactic drugs for oxaliplatin-induced peripheral neuropathy using big data. Biomed Pharmacother. 148, 112744. (2022)
  6. Fukushima K, Senoo K, Kurata N, Regan JW, Fujino H. The Gαs-protein-mediated pathway may be steadily stimulated by prostanoid EP2 receptors, but not by EP4 receptors. FEBS Open Bio. 12, 775-783. (2022)
  7. Mashimo M*, Shimizu A, Mori A, Hamaguchi A, Fukushima K, Seira N, Fujii T, Fujino H*. PARP14 regulates EP4 receptor expression in human colon cancer HCA-7 cells. Biochem. Biophys. Res. Commun., 623, 133-139. (2022)
  8. Fukushima K, Fujino H*. Identification and characterization of human colorectal cancer cluster predominantly expressing EP3 prostanoid receptor subtype. Biol. Pharm. Bull., 45, 698-702. (2022)
  9. Fukushima K, Takahashi T, Suzuki T*. Characterization of human parainfluenza virus receptor using terminal sialic acid linage-modified cells. Methods Mol. Biol., 2556, 169-178. (2022)

2021年

  1. Fujino H. Why PGD2 has different functions from PGE2. Bioessays. 43, e2000213. (2021)
  2. Suzuki M, Urabe A, Sasaki S, Tsugawa R, Nishio S, Mukaiyama H, Murata Y, Masuda H, Aung MS, Mera A, Takeuchi M, Fukushima K, Kanaki M, Kobayashi K, Chiba Y, Shrestha BB, Nakanishi H, Watanabe T, Nakayama A, Fujino H, Kobayashi T, Tanino K, Nishizawa NK, Namba K. Development of a mugineic acid family phytosiderophore analog as an iron fertilizer. Nat Commun. 12, 1558. (2021)
  3. Okura I, Hasuoka N, Senoo K, Suganami A, Fukushima K, Regan JW, Mashimo M, Murayama T, Tamura Y, Fujino H. The differential functional coupling of phosphodiesterase 4 to human DP and EP2 prostanoid receptors stimulated with PGD2 or PGE2. Pharmacol Rep. 73, 946-953. (2021)
  4. Hamano H, Ikeda Y, Goda M, Fukushima K, Kishi S, Chuma M, Yamashita M, Niimura T, Takechi K, Imanishi M, Zamami Y, Horinouchi Y, Izawa-Ishizawa Y, Miyamoto L, Ishizawa K, Fujino H, Tamaki T, Aihara KI, Tsuchiya K. Diphenhydramine may be a preventive medicine against cisplatin-induced kidney toxicity. Kidney Int. 99, 885-899. (2021)
  5. Suzuki M, Urabe A, Sasaki S, Tsugawa R, Nishio S, Mukaiyama H, Murata Y, Masuda H, Aung MS, Mera A, Takeuchi M, Fukushima K, Kanaki M, Kobayashi K, Chiba Y, Shrestha BB, Nakanishi H, Watanabe T, Nakayama A, Fujino H, Kobayashi T, Tanino K, Nishizawa NK, Namba K. Development of a mugineic acid family phytosiderophore analog as an iron fertilizer. Nat Commun. 12, 1558. (2021)

2020年

  1. Endo S, Suganami A, Fukushima K, Senoo K, Araki Y, Regan JW, Mashimo M, Tamura Y, Fujino H. 15-Keto-PGE2 acts as a biased/partial agonist to terminate PGE2-evoked signaling. J Biol Chem. 295, 13338-13352. (2020)
  2. Imanishi M, Yamakawa Y, Fukushima K, Ikuto R, Maegawa A, Izawa-Ishizawa Y, Horinouchi Y, Kondo M, Kishuku M, Goda M, Zamami Y, Takechi K, Chuma M, Ikeda Y, Tsuchiya K, Fujino H, Tsuneyama K, Ishizawa K. Fibroblast-specific ERK5 deficiency changes tumor vasculature and exacerbates tumor progression in a mouse model. Naunyn Schmiedebergs Arch Pharmacol. 393, 1239-1250. (2020)
  3. Hamano H, Niimura T, Horinouchi Y, Zamami Y, Takechi K, Goda M, Imanishi M, Chuma M, Izawa-Ishizawa Y, Miyamoto L, Fukushima K, Fujino H, Tsuchiya K, Ishizawa K, Tamaki T, Ikeda Y. Proton pump inhibitors block iron absorption through direct regulation of hepcidin via the aryl hydrocarbon receptor-mediated pathway. Toxicol Lett. 318, 86-91. (2020)

2019年

  1. Kurata N, Tokashiki N, Fukushima K, Misao T, Hasuoka N, Kitagawa K, Mashimo M, Regan JW, Murayama T, Fujino H. Short chain fatty acid butyrate uptake reduces expressions of prostanoid EP4 receptors and their mediation of cyclooxygenase-2 induction in HCA-7 human colon cancer cells. Eur J Pharmacol., 853, 308-315. (2019)
  2. Kondo M, Imanishi M, Fukushima K, Ikuto R, Murai Y, Horinouchi Y, Izawa-Ishizawa Y, Goda M, Zamami Y, Takechi K, Chuma M, Ikeda Y, Fujino H, Tsuchiya K, Ishizawa K. Xanthine Oxidase Inhibition by Febuxostat in Macrophages Suppresses Angiotensin II-Induced Aortic Fibrosis. Am. J. Hypertens. 32, 249-256. (2019)
  3. Hamano H, Mitsui M, Zamami Y, Takechi K, Nimura T, Okada N, Fukushima K, Imanishi M, Chuma M, Horinouchi Y, Izawa-Ishizawa Y, Kirino Y, Nakamura T, Teraoka K, Ikeda Y, Fujino H, Yanagawa H, Tamaki T, Ishizawa K. Irinotecan-induced neutropenia is reduced by oral alkalization drugs: analysis using retrospective chart reviews and the spontaneous reporting database. Support Care Cancer. 27, 849-856. (2019)
  4. Zamami Y, Niimura T, Okada N, Koyama T, Fukushima K, Izawa-Ishizawa Y, Ishizawa K. Factors Associated With Immune Checkpoint Inhibitor-Related Myocarditis. JAMA Oncol. (2019)
  5. Fukushima K, Takahashi T, Takaguchi M, Ito S, Suzuki C, Agarikuchi T, Kurebayashi Y, Minami A, Suzuki T. A I131V Substitution in the Fusion Glycoprotein of Human Parainfluenza Virus Type 1 Enhances Syncytium Formation and Virus Growth. Biol Pharm Bull., 42, 827-832. (2019)

2018年

  1. Seira N, Yamagata K, Fukushima K, Araki Y, Kurata N, Yanagisawa N, Mashimo M, Nakamura H, Regan JW, Murayama T, Fujino H*. Cellular density-dependent increases in HIF-1α compete with c-Myc to down-regulate human EP4 receptor promoter activity through Sp-1-binding region. Pharmacol. Res. Perspect. 6, e00441. (2018)
  2. Imanishi M, Izawa-Ishizawa Y, Sakurada T, Kohara Y, Horinouchi Y, Sairyo E, Zamami Y, Takechi K, Chuma M, Fukushima K, Ikeda Y, Fujino H, Yoshizumi M, Tsuchiya K, Tamaki T, Ishizawa K*. Nitrosonifedipine, a Photodegradation Product of Nifedipine, Suppresses Pharmacologically Induced Aortic Aneurysm Formation. Pharmacology. 102, 287-299. (2018)
  3. Horinouchi Y, Ikeda Y, Fukushima K, Imanishi M, Hamano H, Izawa-Ishizawa Y, Zamami Y, Takechi K, Miyamoto L, Fujino H, Ishizawa K, Tsuchiya K, Tamaki T*. Renoprotective effects of a factor Xa inhibitor: fusion of basic research and a database analysis. Sci. Rep. 8, 10858. (2018)

2017年

  1. Seira N, Yanagisawa N, Suganami A, Honda T, Wasai M, Regan JW, Fukushima K, Yamaguchi N, Tamura Y, Arai T, Murayama T, Fujino H*. Anti-cancer Effects of MW-03, a Novel Indole Compound, by Inducing 15-Hydroxyprostaglandin Dehydrogenase and Cellular Growth Inhibition in the LS174T Human Colon Cancer Cell Line. Biol. Pharm. Bull. 40, 1806-1812. (2017)
  2. Araki Y, Suganami A, Endo S, Masuda Y, Fukushima K, Regan JW, Murayama T, Tamura Y, Fujino H*. PGE1 and E3 show lower efficacies than E2 to β-catenin-mediated activity as biased ligands of EP4 prostanoid receptors. FEBS Lett. 591, 3771-3780. (2017)
  3. Niimura T, Zamami Y, Koyama T, Izawa-Ishizawa Y, Miyake M, Koga T, Harada K, Ohshima A, Imai T, Kondo Y, Imanishi M, Takechi K, Fukushima K, Horinouchi Y, Ikeda Y, Fujino H, Tsuchiya K, Tamaki T, Hinotsu S, Kano MR, Ishizawa K*. Hydrocortisone administration was associated with improved survival in Japanese patients with cardiac arrest. Sci. Rep. 7, 17919. (2017)

2016年

  1. Suganami A, Fujino H*, Okura I, Yanagisawa N, Sugiyama H, Regan JW, Tamura Y, Murayama T. Human DP and EP2 prostanoid receptors take on distinct forms depending on the diverse binding of different ligands. FEBS J. 283:3931-3949. (2016)
  2. Fujino H*. The roles of EP4 prostanoid receptors on cancer malignancy signaling. Biol Pharm Bull. 39:149-155 (2016)

2015年

  1. Tanimoto J, Fujino H*, Takahashi H, Murayama T. Human EP2 prostanoid receptors exhibit more constrains to mutations than human DP prostanoid receptors. FEBS Lett. 589:766-772. (2015)
  2. Otake S, Yoshida K, Seira N, Sanchez CM, Regan JW, Fujino H*, Murayama T. Cellular density-dependent down-regulation of EP4 prostanoid receptors via the up-regulation of hypoxia-inducible factor-1α in HCA-7 human colon cancer cells. Pharma Res Per. 3:e00083. (2015)
  3. Yamane S, Nomura R, Yanagihara M, Nakamura H, Fujino H, Matsumoto K, Horie S, Murayama T. L-cycteine/d,L-homocysteine-regulated ileum motility via system L and Bo (,+) transporter: Modification by inhibitors of hydrogen sulfide synthesis and dietary treatments. Eur J Pharmacol. 764:471-479. (2015)
  4. Fujino H*, Seira N, Kurata N, Araki Y, Nakamura H, Regan JW, Murayama T. Prostaglandin E2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin E2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase A in HCA-7 human colon cancer cells. Eur J Pharmacol. 768:149-159. (2015)
  5. Kawahara T., Takahashi T., Oishi K., Tanaka H., Masuda M., Takahashi S., Takano M., Kawakami T., Fukushima K., Kanazawa H., *Suzuki T., Consecutive oral administration of Bifidobacterium longum MM-2 improves the defense system against influenza virus infection by enhancing natural killer cell activity in a murine model. Microbiol. Immunol. 59, 1-12 (2015)
  6. Fukushima K., Takahashi T., Ueyama H., Takaguchi M., Ito S., Oishi K., Minami A., Ishitsubo E., Tokiwa H., Takimoto T., *Suzuki T., Amino acid substitutions contributing to α2,6-sialic acid linkage binding specificity of human parainfluenza virus type 3 hemagglutinin-neuraminidase. FEBS Lett. 589, 2389-1282 (2015)
  7. Takahashi T., Takano M., Kurebayashi Y., Agarikuchi T., Suzuki C., Fukushima K., Takahashi S., Otsubo T., Ikeda K., Minami A., *Suzuki T., Rapid Fluorescent Detection Assay for Human Parainfluenza Viruses. Biol. Pharm. Bull. 38, 1214-1219 (2015)
  8. Takahashi T., Agarikuchi T., Kurebayashi Y., Shibahara N., Suzuki C., Kishikawa A., Fukushima K., Takano M., Suzuki F., Wada H., Otsubo T., Ikeda K., Minami A., *Suzuki T., Easy and Rapid Detection of Mumps Virus by Live Fluorescent Visualization of Virus-Infected Cells. PLoS One. 10, e0144038 (2015)

2014年

  1. Oyama S, Fujino H*, Yamazaki R, Okura I, Regan JW, Awata A, Arai T, Murayama T. A novel indole compound, AWT-489, inhibits prostaglandin D2-induced CD55 expression by acting on DP prostanoid receptors as an antagonist in LS174T human colon cancer cells. Arch Biochem Biophys. 541:21-29. (2014)
  2. Hosoya T, Matsumoto K, Tashima K, Nakamura H, Fujino H, Murayama T, Horie S. TRPM8 has a key role in experimental colitis-induced visceral hyperalgesia in mice. Neurogastroenterol Motil. 26:1112-1121. (2014)
  3. Yamane S, Kanno T, Nakamura H, Fujino H, Murayama T. Hydrogen sulfide-mediated regulation of contractility in the mouse ileum with electrical stimulation: Roles of l-cysteine, cystathionine β-synthase, and K+ channels. Eur J Pharmacol. 740:112-120. (2014)
  4. Fukushima K., Takahashi T., Ito S., Takaguchi M.,Takano M. Kurebayashi Y. Oishi K. Minami A. Kato T. Park E.Y. Nishimura H., Takimoto T., Suzuki T*., Terminal sialic acid linkages determine different cell infectivities of human parainfluenza virus type 1 and type 3. Virology, 464-465, 424-431 (2014)

2013年

  1. Yoshida K, Fujino H*, Otake S, Seira N, Regan JW, Murayama T. Induction of cyclooxygenase-2 expression by prostaglandin E2 stimulation of the prostanoid EP4 receptor via coupling to Gαi and transactivation of the epidermal growth factor receptor in HCA-7 human colon cancer cells. Eur J Pharmacol. 718:408-417. (2013)
  2. Nomura R, Yanagihara M, Sato H, Matsumoto K, Tashima K, Horie S, Chen S, Fujino H, Ueno K, Murayama T*. Bee venom phospholipase A2-induced phasic contractions in mouse rectum: independent roles of eicosanoid and gap junction proteins and their loss in experimental colitis. Eur J Pharmacol. 718:314-322. (2013)

2012年

  1. Nakamura H, Yasufuku K, Makiyama T, Matsumoto I, Fujino H, Murayama T. Arachidonic acid metabolism via cytosolic phospholipase A2α induces cytotoxicity in Nemann-Pick disease type C cells. J Cell Physiol. 227:2847-2855. (2012)
  2. Kato E, Yamane S, Nomura R, Matsumoto K, Tashima K, Horie S, Saito T, Fujino H, Murayama T. Dysfunction of neurogenic VIP-mediated relaxation in mouse distal colon with dextran sulfate sodium-induced colitis. Pharmacol Res. 65:204-212. (2012)
  3. Hamada Y, Kato E, Nakamura H, Fujino H, Matsumoto K, Tashima K, Horie S, Murayama T. Decrease of guanylyl cyclase β1 subunit and nitric oxide (NO)-induced relaxation in mouse rectum with colitis and its reproduction on long-term NO treatment. Naunyn Schmiedebergs Arch Pharmacol. 385:81-94. (2012)
  4. Ikawa Y, Fujino H*, Otake S, Murayama T. Indomethacin antagonizes EP2 prostanoid receptor activation in LS174T human colon cancer cells. Eur J Pharmacol. 680:16-21. (2012)
  5. Kawashima T, Yamazaki R, Matsuzawa Y, Yamaura E, Takabatake M, Otake S, Ikawa Y, Nakamura H, Fujino H, Murayama T. Contrary effects of sphingosine-1-phosphate on expression of α-smooth muscle actin in transforming growth factor β1-stimulated lung fibroblasts. Eur J Pharmacol. 696:120-129. (2012)
  6. Takahashi T., Ito K., Fukushima K., Takaguchi M., Hayakawa T., Suzuki Y., Suzuki T*., Sulfatide negatively regulates the fusion process of human parainfluenza virus type 3. J. Biochem. 152, 373-380 (2012)
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