(2022/10/22 updated)

2021�ꡫ�F��

Masaki Imanishi, Haizi Cheng, Sivareddy Kotla, Anita Deswal, Nhat-Tu Le, Eduardo Chini, Kyung Ae Ko, Venkatasubrahman K Samanthapudi, Ling-Ling Lee, Joerg Herrmann, Xiolei Xu, Cielito Reyes-Gibby, Sai-ching J. Yeung, Keri L. Schadler, Syed Wamique Yusuf, Zhongxing Liao, Roza Nurieva, El-ad David Amir, Jared K. Burks, Nicolas L. Palaskas, Steven H. Lin, Michihiro Kobayashi, Momoko Yoshimoto, Jun-ichi Abe. Radiation therapy induces immunosenescence mediated by p90RSK. Front Cardiovasc Med. 2022, in press

1: Wang Y, Abe JI, Chau KM, Wang Y, Vu HT, Reddy Velatooru L, Gulraiz F,
Imanishi M, Samanthapudi VSK, Nguyen MTH, Ko KA, Lee LL, Thomas TN, Olmsted-
Davis EA, Kotla S, Fujiwara K, Cooke JP, Zhao D, Evans SE, Le NT. MAGI1 inhibits
interferon signaling to promote influenza A infection. Front Cardiovasc Med.
2022 Aug 23;9:791143. doi: 10.3389/fcvm.2022.791143. PMID: 36082118; PMCID:
PMC9445416.

2: Ikeda Y, Funamoto M, Kishi S, Imanishi M, Aihara KI, Kashiwada Y, Tsuchiya K.
The novel preventive effect of a Japanese ethical Kampo extract formulation
TJ-90 (Seihaito) against cisplatin-induced nephrotoxicity. Phytomedicine. 2022
Aug;103:154213. doi: 10.1016/j.phymed.2022.154213. Epub 2022 May 29. PMID:
35671634.

3: Ikeda Y, Funamoto M, Tsuchiya K. The role of iron in obesity and diabetes. J
Med Invest. 2022;69(1.2):1-7. doi: 10.2152/jmi.69.1. PMID: 35466128.

4: Shirai A, Kawasaka K, Tsuchiya K. Antimicrobial action of phenolic acids
combined with violet 405-nm light for disinfecting pathogenic and spoilage
fungi. J Photochem Photobiol B. 2022 Apr;229:112411. doi:
10.1016/j.jphotobiol.2022.112411. Epub 2022 Feb 18. PMID: 35219030.

5: Shirai A, Kunimi H, Tsuchiya K. Antifungal action of the combination of
ferulic acid and ultraviolet-A irradiation against Saccharomyces cerevisiae. J
Appl Microbiol. 2022 Apr;132(4):2957-2967. doi: 10.1111/jam.15407. Epub 2021 Dec
20. PMID: 34894031.

6: Ali H, Morito K, Hasi RY, Aihara M, Hayashi J, Kawakami R, Kanemaru K,
Tsuchiya K, Sango K, Tanaka T. Characterization of uptake and metabolism of very
long-chain fatty acids in peroxisome-deficient CHO cells. Biochim Biophys Acta
Mol Cell Biol Lipids. 2022 Feb;1867(2):159088. doi:
10.1016/j.bbalip.2021.159088. Epub 2021 Nov 27. PMID: 34848380.

7: Kotla S, Zhang A, Imanishi M, Ko KA, Lin SH, Gi YJ, Moczygemba M, Isgandarova
S, Schadler KL, Chung C, Milgrom SA, Banchs J, Yusuf SW, Amaya DN, Guo H, Thomas
TN, Shen YH, Deswal A, Herrmann J, Kleinerman ES, Entman ML, Cooke JP, Schifitto
G, Maggirwar SB, McBeath E, Gupte AA, Krishnan S, Patel ZS, Yoon Y, Burks JK,
Fujiwara K, Brookes PS, Le NT, Hamilton DJ, Abe JI. Nucleus-mitochondria
positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-
ribose) polymerase activation provokes persistent pro-inflammatory senescent
phenotype and accelerates coronary atherosclerosis after chemo-radiation. Redox
Biol. 2021 Nov;47:102132. doi: 10.1016/j.redox.2021.102132. Epub 2021 Sep 20.
PMID: 34619528; PMCID: PMC8502954.

8: Velatooru LR, Abe RJ, Imanishi M, Gi YJ, Ko KA, Heo KS, Fujiwara K, Le NT,
Kotla S. Disturbed flow-induced FAK K152 SUMOylation initiates the formation of
pro-inflammation positive feedback loop by inducing reactive oxygen species
production in endothelial cells. Free Radic Biol Med. 2021 Dec;177:404-418. doi:
10.1016/j.freeradbiomed.2021.09.023. Epub 2021 Oct 5. PMID: 34619327; PMCID:
PMC8664087.

9: Kobayashi D, Kohmura Y, Hayashi J, Denda M, Tsuchiya K, Otaka A.
Copper(II)-mediated C-H sulphenylation or selenylation of tryptophan enabling
macrocyclization of peptides. Chem Commun (Camb). 2021 Oct
14;57(82):10763-10766. doi: 10.1039/d1cc04856b. PMID: 34585682.

10: Minamikawa T, Koma T, Suzuki A, Mizuno T, Nagamatsu K, Arimochi H, Tsuchiya
K, Matsuoka K, Yasui T, Yasutomo K, Nomaguchi M. Publisher Correction:
Quantitative evaluation of SARS-CoV-2 inactivation using a deep ultraviolet
light-emitting diode. Sci Rep. 2021 Aug 4;11(1):16221. doi:
10.1038/s41598-021-94999-4. Erratum for: Sci Rep. 2021 Mar 3;11(1):5070. PMID:
34349167; PMCID: PMC8335707.

11: Ikeda Y, Hamano H, Horinouchi Y, Miyamoto L, Hirayama T, Nagasawa H, Tamaki
T, Tsuchiya K. Role of ferroptosis in cisplatin-induced acute nephrotoxicity in
mice. J Trace Elem Med Biol. 2021 Sep;67:126798. doi:
10.1016/j.jtemb.2021.126798. Epub 2021 May 28. PMID: 34087581.

12: Takahashi S, Takechi K, Jozukuri N, Niimura T, Chuma M, Goda M, Zamami Y,
Izawa-Ishizawa Y, Imanishi M, Horinouchi Y, Ikeda Y, Tsuchiya K, Yanagawa H,
Ishizawa K. Examination of the antiepileptic effects of valacyclovir using
kindling mice- search for novel antiepileptic agents by drug repositioning using
a large medical information database. Eur J Pharmacol. 2021 Jul 5;902:174099.
doi: 10.1016/j.ejphar.2021.174099. Epub 2021 Apr 25. PMID: 33910036.

13: Abe RJ, Savage H, Imanishi M, Banerjee P, Kotla S, Paez-Mayorga J, Taunton
J, Fujiwara K, Won JH, Yusuf SW, Palaskas NL, Banchs J, Lin SH, Schadler KL, Abe
JI, Le NT. Corrigendum: p90RSK-MAGI1 Module Controls Endothelial Permeability by
Post-translational Modifications of MAGI1 and Hippo Pathway. Front Cardiovasc
Med. 2021 Feb 19;8:663486. doi: 10.3389/fcvm.2021.663486. Erratum for: Front
Cardiovasc Med. 2020 Nov 13;7:542485. PMID: 33681312; PMCID: PMC7934140.

14: Minamikawa T, Koma T, Suzuki A, Mizuno T, Nagamatsu K, Arimochi H, Tsuchiya
K, Matsuoka K, Yasui T, Yasutomo K, Nomaguchi M. Quantitative evaluation of
SARS-CoV-2 inactivation using a deep ultraviolet light-emitting diode. Sci Rep.
2021 Mar 3;11(1):5070. doi: 10.1038/s41598-021-84592-0. Erratum in: Sci Rep.
2021 Aug 4;11(1):16221. PMID: 33658595; PMCID: PMC7930116.

2014�ꡫ2020��

1: Hamano H, Ikeda Y, Goda M, Fukushima K, Kishi S, Chuma M, Yamashita M,
Niimura T, Takechi K, Imanishi M, Zamami Y, Horinouchi Y, Izawa-Ishizawa Y,
Miyamoto L, Ishizawa K, Fujino H, Tamaki T, Aihara KI, Tsuchiya K.
Diphenhydramine may be a preventive medicine against cisplatin-induced kidney
toxicity. Kidney Int. 2021 Apr;99(4):885-899. doi: 10.1016/j.kint.2020.10.041.
Epub 2020 Dec 9. PMID: 33307103.

2: Abe RJ, Savage H, Imanishi M, Banerjee P, Kotla S, Paez-Mayorga J, Taunton J,
Fujiwara K, Won JH, Yusuf SW, Palaskas NL, Banchs J, Lin SH, Schadler KL, Abe
JI, Le NT. p90RSK-MAGI1 Module Controls Endothelial Permeability by Post-
translational Modifications of MAGI1 and Hippo Pathway. Front Cardiovasc Med.
2020 Nov 13;7:542485. doi: 10.3389/fcvm.2020.542485. Erratum in: Front
Cardiovasc Med. 2021 Feb 19;8:663486. PMID: 33304925; PMCID: PMC7693647.

3: Ali H, Yamashita R, Morishige JI, Morito K, Kakiuchi N, Hayashi J, Aihara M,
Kawakami R, Tsuchiya K, Tanaka T. Mass Spectrometric Analysis of Sphingomyelin
with N-α-Hydroxy Fatty Acyl Residue in Mouse Tissues. Lipids. 2021
Mar;56(2):181-188. doi: 10.1002/lipd.12285. Epub 2020 Sep 30. PMID: 32996178.

4: Miyamoto L, Sato H. [State-of-the-art Technologies Innovative to the World of
Pharmaceutical Sciences]. Yakugaku Zasshi. 2020;140(8):961-962. Japanese. doi:
10.1248/yakushi.20-00012-F. PMID: 32741868.

5: Miyamoto L, Abe S, Nemoto H, Tsuchiya K. [Conjugation to Branched Glycerol
Oligomers, a Novel Strategy for Extremely Hydrophobic Agents]. Yakugaku Zasshi.
2020;140(8):1001-1006. Japanese. doi: 10.1248/yakushi.20-00012-6. PMID:
32741857.

6: Miyamoto L, Tsuchiya K. [Metabolic beneficial effects of Citrus Sudachi].
Nihon Yakurigaku Zasshi. 2020;155(4):220-223. Japanese. doi: 10.1254/fpj.20025.
PMID: 32612032.

7: Miyamoto L, Okuyama S. [Preface]. Nihon Yakurigaku Zasshi. 2020;155(4):201.
Japanese. doi: 10.1254/fpj20026. PMID: 32612028.

8: Ikeda Y, Watanabe H, Shiuchi T, Hamano H, Horinouchi Y, Imanishi M, Goda M,
Zamami Y, Takechi K, Izawa-Ishizawa Y, Miyamoto L, Ishizawa K, Aihara KI,
Tsuchiya K, Tamaki T. Deletion of H-ferritin in macrophages alleviates obesity
and diabetes induced by high-fat diet in mice. Diabetologia. 2020
Aug;63(8):1588-1602. doi: 10.1007/s00125-020-05153-0. Epub 2020 May 19. PMID:
32430665.

9: Imanishi M, Yamakawa Y, Fukushima K, Ikuto R, Maegawa A, Izawa-Ishizawa Y,
Horinouchi Y, Kondo M, Kishuku M, Goda M, Zamami Y, Takechi K, Chuma M, Ikeda Y,
Tsuchiya K, Fujino H, Tsuneyama K, Ishizawa K. Fibroblast-specific ERK5
deficiency changes tumor vasculature and exacerbates tumor progression in a
mouse model. Naunyn Schmiedebergs Arch Pharmacol. 2020 Jul;393(7):1239-1250.
doi: 10.1007/s00210-020-01859-5. Epub 2020 Apr 19. PMID: 32307577.

10: Tsuchihashi Y, Abe S, Miyamoto L, Tsunematsu H, Izumi T, Hatano A, Okuno H,
Yamane M, Yasuoka T, Ikeda Y, Tsuchiya K. Novel Hydrophilic Camptothecin
Derivatives Conjugated to Branched Glycerol Trimer Suppress Tumor Growth without
Causing Diarrhea in Murine Xenograft Models of Human Lung Cancer. Mol Pharm.
2020 Apr 6;17(4):1049-1058. doi: 10.1021/acs.molpharmaceut.9b00249. Epub 2020
Mar 4. PMID: 32068412.

11: Tsuda T, Imanishi M, Oogoshi M, Goda M, Kihira Y, Horinouchi Y, Zamami Y,
Ishizawa K, Ikeda Y, Hashimoto I, Tamaki T, Izawa-Ishizawa Y. Rho-associated
protein kinase and cyclophilin a are involved in inorganic phosphate-induced
calcification signaling in vascular smooth muscle cells. J Pharmacol Sci. 2020
Mar;142(3):109-115. doi: 10.1016/j.jphs.2019.12.005. Epub 2019 Dec 16. PMID:
31882204.

12: Zamami Y, Niimura T, Koyama T, Shigemi Y, Izawa-Ishizawa Y, Morita M,
Ohshima A, Harada K, Imai T, Hagiwara H, Okada N, Goda M, Takechi K, Chuma M,
Kondo Y, Tsuchiya K, Hinotsu S, Kano MR, Ishizawa K. Search for Therapeutic
Agents for Cardiac Arrest Using a Drug Discovery Tool and Large-Scale Medical
Information Database. Front Pharmacol. 2019 Nov 8;10:1257. doi:
10.3389/fphar.2019.01257. PMID: 31780928; PMCID: PMC6857070.

13: Konaka K, Sakurada T, Saito T, Mori S, Imanishi M, Kakiuchi S, Fushitani S,
Ishizawa K. Study on the Optimal Dose of Irinotecan for Patients with
Heterozygous Uridine Diphosphate-Glucuronosyltransferase 1A1 (UGT1A1). Biol
Pharm Bull. 2019;42(11):1839-1845. doi: 10.1248/bpb.b19-00357. PMID: 31685767.

14: Hamano H, Niimura T, Horinouchi Y, Zamami Y, Takechi K, Goda M, Imanishi M,
Chuma M, Izawa-Ishizawa Y, Miyamoto L, Fukushima K, Fujino H, Tsuchiya K,
Ishizawa K, Tamaki T, Ikeda Y. Proton pump inhibitors block iron absorption
through direct regulation of hepcidin via the aryl hydrocarbon receptor-mediated
pathway. Toxicol Lett. 2020 Jan;318:86-91. doi: 10.1016/j.toxlet.2019.10.016.
Epub 2019 Oct 24. PMID: 31669099.

15: Ikeda Y, Satoh A, Horinouchi Y, Hamano H, Watanabe H, Imao M, Imanishi M,
Zamami Y, Takechi K, Izawa-Ishizawa Y, Miyamoto L, Hirayama T, Nagasawa H,
Ishizawa K, Aihara KI, Tsuchiya K, Tamaki T. Iron accumulation causes impaired
myogenesis correlated with MAPK signaling pathway inhibition by oxidative
stress. FASEB J. 2019 Aug;33(8):9551-9564. doi: 10.1096/fj.201802724RR. Epub
2019 May 30. PMID: 31145863.

16: Kotla S, Vu HT, Ko KA, Wang Y, Imanishi M, Heo KS, Fujii Y, Thomas TN, Gi
YJ, Mazhar H, Paez-Mayorga J, Shin JH, Tao Y, Giancursio CJ, Medina JL, Taunton
J, Lusis AJ, Cooke JP, Fujiwara K, Le NT, Abe JI. Endothelial senescence is
induced by phosphorylation and nuclear export of telomeric repeat binding factor
2-interacting protein. JCI Insight. 2019 May 2;4(9):e124867. doi:
10.1172/jci.insight.124867. PMID: 31045573; PMCID: PMC6538340.

17: Abe JI, Ko KA, Kotla S, Wang Y, Paez-Mayorga J, Shin IJ, Imanishi M, Vu HT,
Tao Y, Leiva-Juarez MM, Thomas TN, Medina JL, Won JH, Fujii Y, Giancursio CJ,
McBeath E, Shin JH, Guzman L, Abe RJ, Taunton J, Mochizuki N, Faubion W, Cooke
JP, Fujiwara K, Evans SE, Le NT. MAGI1 as a link between endothelial activation
and ER stress drives atherosclerosis. JCI Insight. 2019 Apr 4;4(7):e125570. doi:
10.1172/jci.insight.125570. PMID: 30944250; PMCID: PMC6483653.

18: Okada N, Niimura T, Zamami Y, Hamano H, Ishida S, Goda M, Takechi K, Chuma
M, Imanishi M, Ishizawa K. Pharmacovigilance evaluation of the relationship
between impaired glucose metabolism and BCR-ABL inhibitor use by using an
adverse drug event reporting database. Cancer Med. 2019 Jan;8(1):174-181. doi:
10.1002/cam4.1920. Epub 2018 Dec 18. PMID: 30561126; PMCID: PMC6346261.

19: Okada N, Kawazoe H, Takechi K, Matsudate Y, Utsunomiya R, Zamami Y, Goda M,
Imanishi M, Chuma M, Hidaka N, Sayama K, Kubo Y, Tanaka A, Ishizawa K.
Association Between Immune-Related Adverse Events and Clinical Efficacy in
Patients with Melanoma Treated With Nivolumab: A Multicenter Retrospective
Study. Clin Ther. 2019 Jan;41(1):59-67. doi: 10.1016/j.clinthera.2018.11.004.
Epub 2018 Dec 7. PMID: 30528047.

20: Zhou Y, Yamamura Y, Ogawa M, Tsuji R, Tsuchiya K, Kasahara J, Goto S. c-Abl
Inhibition Exerts Symptomatic Antiparkinsonian Effects Through a Striatal
Postsynaptic Mechanism. Front Pharmacol. 2018 Nov 16;9:1311. doi:
10.3389/fphar.2018.01311. PMID: 30505273; PMCID: PMC6250819.

21: Kondo M, Imanishi M, Fukushima K, Ikuto R, Murai Y, Horinouchi Y, Izawa-
Ishizawa Y, Goda M, Zamami Y, Takechi K, Chuma M, Ikeda Y, Fujino H, Tsuchiya K,
Ishizawa K. Xanthine Oxidase Inhibition by Febuxostat in Macrophages Suppresses
Angiotensin II-Induced Aortic Fibrosis. Am J Hypertens. 2019 Feb
12;32(3):249-256. doi: 10.1093/ajh/hpy157. PMID: 30351343; PMCID: PMC7110082.

22: Izawa-Ishizawa Y, Imanishi M, Zamami Y, Toya H, Nagao T, Morishita M,
Tsuneyama K, Horinouchi Y, Kihira Y, Takechi K, Ikeda Y, Tsuchiya K, Yoshizumi
M, Tamaki T, Ishizawa K. Development of a novel aortic dissection mouse model
and evaluation of drug efficacy using in-vivo assays and database analyses. J
Hypertens. 2019 Jan;37(1):73-83. doi: 10.1097/HJH.0000000000001898. PMID:
30303488.

23: Xu W, Miyamoto L, Aihara H, Yamaoka T, Tanaka N, Tsuchihashi Y, Ikeda Y,
Tamaki T, Kashiwada Y, Tsuchiya K. Methanol extraction fraction from Citrus
Sudachi peel exerts lipid reducing effects in cultured cells. J Med Invest.
2018;65(3.4):225-230. doi: 10.2152/jmi.65.225. PMID: 30282865.

24: Miyamoto L. [AMPK as a Metabolic Intersection between Diet and Physical
Exercise]. Yakugaku Zasshi. 2018;138(10):1291-1296. Japanese. doi:
10.1248/yakushi.18-00091-6. PMID: 30270274.

25: Miyamoto L, Nishida M. [Lifestyle Inspires Future Pharmacotherapy and Drug
Discovery]. Yakugaku Zasshi. 2018;138(10):1255-1256. Japanese. doi:
10.1248/yakushi.18-00091-F. PMID: 30270268.

26: Imanishi M, Izawa-Ishizawa Y, Sakurada T, Kohara Y, Horinouchi Y, Sairyo E,
Zamami Y, Takechi K, Chuma M, Fukushima K, Ikeda Y, Fujino H, Yoshizumi M,
Tsuchiya K, Tamaki T, Ishizawa K. Nitrosonifedipine, a Photodegradation Product
of Nifedipine, Suppresses Pharmacologically Induced Aortic Aneurysm Formation.
Pharmacology. 2018;102(5-6):287-299. doi: 10.1159/000492577. Epub 2018 Sep 25.
PMID: 30253416.

27: Ishida S, Takechi K, Bando H, Imanishi M, Zamami Y, Chuma M, Yanagawa H,
Kirino Y, Nakamura T, Teraoka K, Ishizawa K. Development and pharmacist-mediated
use of tools for monitoring atypical antipsychotic-induced side effects related
to blood glucose levels. Pharmacoepidemiol Drug Saf. 2018 Dec;27(12):1379-1384.
doi: 10.1002/pds.4656. Epub 2018 Sep 17. PMID: 30221424.

28: Hamano H, Mitsui M, Zamami Y, Takechi K, Nimura T, Okada N, Fukushima K,
Imanishi M, Chuma M, Horinouchi Y, Izawa-Ishizawa Y, Kirino Y, Nakamura T,
Teraoka K, Ikeda Y, Fujino H, Yanagawa H, Tamaki T, Ishizawa K. Irinotecan-
induced neutropenia is reduced by oral alkalization drugs: analysis using
retrospective chart reviews and the spontaneous reporting database. Support Care
Cancer. 2019 Mar;27(3):849-856. doi: 10.1007/s00520-018-4367-y. Epub 2018 Jul
31. PMID: 30062585.

29: Horinouchi Y, Ikeda Y, Fukushima K, Imanishi M, Hamano H, Izawa-Ishizawa Y,
Zamami Y, Takechi K, Miyamoto L, Fujino H, Ishizawa K, Tsuchiya K, Tamaki T.
Renoprotective effects of a factor Xa inhibitor: fusion of basic research and a
database analysis. Sci Rep. 2018 Jul 18;8(1):10858. doi:
10.1038/s41598-018-29008-2. PMID: 30022146; PMCID: PMC6052035.

30: Miyamoto L, Tsuchiya K. [Sodium-Glucose Transporters as a Therapeutic Target
for Diabetes from the Viewpoint of Drug Discovery and Pharmacotherapy]. Yakugaku
Zasshi. 2018;138(7):933-938. Japanese. doi: 10.1248/yakushi.17-00223-1. PMID:
29962472.

31: Tsuda K, Miyamoto L, Hamano S, Morimoto Y, Kangawa Y, Fukue C, Kagawa Y,
Horinouchi Y, Xu W, Ikeda Y, Tamaki T, Tsuchiya K. Mechanisms of the pH- and
Oxygen-Dependent Oxidation Activities of Artesunate. Biol Pharm Bull.
2018;41(4):555-563. doi: 10.1248/bpb.b17-00855. PMID: 29607928.

32: Niimura T, Zamami Y, Imai T, Ito T, Sagara H, Hiroyuki H, Esumi S, Takechi
K, Imanishi M, Koyama T, Amano M, Kurata N, Kitamura Y, Nakura H, Sendo T,
Ishizawa K. Administration of Kampo medicine through a tube at an advanced
critical care center. J Med Invest. 2018;65(1.2):32-36. doi: 10.2152/jmi.65.32.
PMID: 29593190.

33: Miyamoto L. Molecular Pathogenesis of Familial Wolff-Parkinson-White
Syndrome. J Med Invest. 2018;65(1.2):1-8. doi: 10.2152/jmi.65.1. PMID: 29593177.

34: Niimura T, Zamami Y, Imai T, Nagao K, Kayano M, Sagara H, Goda M, Okada N,
Chuma M, Takechi K, Imanishi M, Koyama T, Koga T, Nakura H, Sendo T, Ishizawa K.
Evaluation of the Benefits of De-Escalation for Patients with Sepsis in the
Emergency Intensive Care Unit. J Pharm Pharm Sci. 2018;21(1):54-59. doi:
10.18433/jpps29737. PMID: 29455711.

35: Nagao T, Nakayama-Imaohji H, Elahi M, Tada A, Toyonaga E, Yamasaki H,
Okazaki K, Miyoshi H, Tsuchiya K, Kuwahara T. L?histidine augments the oxidative
damage against Gram?negative bacteria by hydrogen peroxide. Int J Mol Med. 2018
May;41(5):2847-2854. doi: 10.3892/ijmm.2018.3473. Epub 2018 Feb 7. PMID:
29436593.

36: Okada N, Azuma M, Imanishi M, Zamami Y, Kirino Y, Nakamura T, Teraoka K, Abe
M, Ishizawa K. Potential Usefulness of Early Potassium Supplementation for
Preventing Severe Hypokalemia Induced by Liposomal Amphotericin B in Hematologic
Patients: A Retrospective Study. Clin Ther. 2018 Feb;40(2):252-260. doi:
10.1016/j.clinthera.2017.12.006. Epub 2018 Jan 2. PMID: 29305017.

37: Niimura T, Zamami Y, Koyama T, Izawa-Ishizawa Y, Miyake M, Koga T, Harada K,
Ohshima A, Imai T, Kondo Y, Imanishi M, Takechi K, Fukushima K, Horinouchi Y,
Ikeda Y, Fujino H, Tsuchiya K, Tamaki T, Hinotsu S, Kano MR, Ishizawa K.
Hydrocortisone administration was associated with improved survival in Japanese
patients with cardiac arrest. Sci Rep. 2017 Dec 20;7(1):17919. doi:
10.1038/s41598-017-17686-3. PMID: 29263333; PMCID: PMC5738407.

38: Zamami Y, Niimura T, Takechi K, Imanishi M, Koyama T, Ishizawa K. [Drug
Repositioning Research Utilizing a Large-scale Medical Claims Database to
Improve Survival Rates after Cardiopulmonary Arrest]. Yakugaku Zasshi.
2017;137(12):1439-1442. Japanese. doi: 10.1248/yakushi.17-00139-3. PMID:
29199254.

39: Miyamoto L, Yamane M, Tomida Y, Kono M, Yamaoka T, Kawasaki A, Hatano A,
Tsuda K, Xu W, Ikeda Y, Tamaki T, Tsuchiya K. Nitrite Activates 5'AMP-Activated
Protein Kinase-Endothelial Nitric Oxide Synthase Pathway in Human Glomerular
Endothelial Cells. Biol Pharm Bull. 2017;40(11):1866-1872. doi:
10.1248/bpb.b17-00316. PMID: 29093333.

40: Hamano H, Ikeda Y, Watanabe H, Horinouchi Y, Izawa-Ishizawa Y, Imanishi M,
Zamami Y, Takechi K, Miyamoto L, Ishizawa K, Tsuchiya K, Tamaki T. The uremic
toxin indoxyl sulfate interferes with iron metabolism by regulating hepcidin in
chronic kidney disease. Nephrol Dial Transplant. 2018 Apr 1;33(4):586-597. doi:
10.1093/ndt/gfx252. PMID: 28992067.

41: Takechi K, Yoshioka Y, Kawazoe H, Tanaka M, Takatori S, Kobayashi M,
Matsuoka I, Yanagawa H, Zamami Y, Imanishi M, Ishizawa K, Tanaka A, Araki H.
Psychiatric Patients with Antipsychotic Drug-Induced Hyperprolactinemia and
Menstruation Disorders. Biol Pharm Bull. 2017;40(10):1775-1778. doi:
10.1248/bpb.b17-00053. PMID: 28966250.

42: Zamami Y, Imanishi M, Takechi K, Ishizawa K. Pharmacological approach for
drug repositioning against cardiorenal diseases. J Med Invest.
2017;64(3.4):197-201. doi: 10.2152/jmi.64.197. PMID: 28954981.

43: Ikeda Y, Horinouchi Y, Hamano H, Hirayama T, Kishi S, Izawa-Ishizawa Y,
Imanishi M, Zamami Y, Takechi K, Miyamoto L, Ishizawa K, Aihara KI, Nagasawa H,
Tsuchiya K, Tamaki T. Dietary iron restriction alleviates renal
tubulointerstitial injury induced by protein overload in mice. Sci Rep. 2017 Sep
6;7(1):10621. doi: 10.1038/s41598-017-11089-0. PMID: 28878231; PMCID:
PMC5587788.

44: Konaka K, Moriyama K, Sakurada T, Okada N, Imanishi M, Zamami Y, Kawazoe K,
Fushitani S, Ishizawa K. Kamishoyosan and Shakuyakukanzoto promote recovery from
paclitaxel-induced neurite retraction in PC12 cells. J Pharm Health Care Sci.
2017 Jul 21;3:20. doi: 10.1186/s40780-017-0090-y. PMID: 28748102; PMCID:
PMC5521132.

45: Nishimura Y, Ueki M, Imanishi M, Tomita S, Ueno M, Morishita J, Nishiyama T.
Reoxygenation with 100% Oxygen Following Hypoxia in Mice Causes Apoptosis.
Shock. 2017 Nov;48(5):590-594. doi: 10.1097/SHK.0000000000000891. PMID:
28472013.

46: Koyama S, Matsunaga S, Imanishi M, Maekawa Y, Kitano H, Takeuchi H, Tomita
S. Tumour blood vessel normalisation by prolyl hydroxylase inhibitor repaired
sensitivity to chemotherapy in a tumour mouse model. Sci Rep. 2017 Mar
31;7:45621. doi: 10.1038/srep45621. PMID: 28361934; PMCID: PMC5374523.

47: Oshima K, Ikeda Y, Horinouchi Y, Watanabe H, Hamano H, Kihira Y, Kishi S,
Izawa-Ishizawa Y, Miyamoto L, Hirayama T, Nagasawa H, Ishizawa K, Tsuchiya K,
Tamaki T. Iron suppresses erythropoietin expression via oxidative stress-
dependent hypoxia-inducible factor-2 alpha inactivation. Lab Invest. 2017
May;97(5):555-566. doi: 10.1038/labinvest.2017.11. Epub 2017 Mar 6. PMID:
28263291.

48: Fukunaga Y, Izawa-Ishizawa Y, Horinouchi Y, Sairyo E, Ikeda Y, Ishizawa K,
Tsuchiya K, Abe Y, Hashimoto I, Tamaki T. Topical application of
nitrosonifedipine, a novel radical scavenger, ameliorates ischemic skin flap
necrosis in a mouse model. Wound Repair Regen. 2017 Apr;25(2):217-223. doi:
10.1111/wrr.12510. Epub 2017 Feb 13. PMID: 28090711.

49: Imanishi M, Chiba Y, Tomita N, Matsunaga S, Nakagawa T, Ueno M, Yamamoto K,
Tamaki T, Tomita S. Hypoxia-Inducible Factor-1α in Smooth Muscle Cells Protects
Against Aortic Aneurysms-Brief Report. Arterioscler Thromb Vasc Biol. 2016
Nov;36(11):2158-2162. doi: 10.1161/ATVBAHA.116.307784. Epub 2016 Aug 25. PMID:
27562915.

50: Zamami Y, Imai T, Imanishi M, Takechi K, Shiraishi N, Koyama T, Sagara H,
Shiino Y, Sendo T, Ishizawa K. Evaluation of pharmaceutical lifesaving skills
training oriented pharmaceutical intervention. J Pharm Health Care Sci. 2016 Sep
7;2(1):21. doi: 10.1186/s40780-016-0054-7. PMID: 27606071; PMCID: PMC5013631.

51: Abe S, Kaneko MK, Tsuchihashi Y, Izumi T, Ogasawara S, Okada N, Sato C,
Tobiume M, Otsuka K, Miyamoto L, Tsuchiya K, Kawazoe K, Kato Y, Nishioka Y.
Antitumor effect of novel anti-podoplanin antibody NZ-12 against malignant
pleural mesothelioma in an orthotopic xenograft model. Cancer Sci. 2016
Sep;107(9):1198-205. doi: 10.1111/cas.12985. Epub 2016 Aug 25. PMID: 27294401;
PMCID: PMC5021042.

52: Miyamoto L. [Novel Strategies for Treating Lifestyle-related Diseases Using
Various Approaches]. Yakugaku Zasshi. 2016;136(5):751-9. Japanese. doi:
10.1248/yakushi.15-00251. PMID: 27150931.

53: Ikeda Y, Imao M, Satoh A, Watanabe H, Hamano H, Horinouchi Y, Izawa-Ishizawa
Y, Kihira Y, Miyamoto L, Ishizawa K, Tsuchiya K, Tamaki T. Iron-induced skeletal
muscle atrophy involves an Akt-forkhead box O3-E3 ubiquitin ligase-dependent
pathway. J Trace Elem Med Biol. 2016 May;35:66-76. doi:
10.1016/j.jtemb.2016.01.011. Epub 2016 Jan 28. PMID: 27049128.

54: Miyamoto L. Can food factors provide Us with the similar beneficial effects
of physical exercise? Food Sci Biotechnol. 2016 Mar 31;25(Suppl 1):9-13. doi:
10.1007/s10068-016-0092-9. PMID: 30263480; PMCID: PMC6049404.

55: Horinouchi Y, Summers FA, Ehrenshaft M, Kawazoe K, Tsuchiya K, Tamaki T,
Mason RP. Investigating free radical generation in HepG2 cells using immuno-spin
trapping. Free Radic Biol Med. 2014 Oct;75 Suppl 1:S33. doi:
10.1016/j.freeradbiomed.2014.10.768. Epub 2014 Dec 10. PMID: 26461344.

56: Ikeda Y, Hamano H, Satoh A, Horinouchi Y, Izawa-Ishizawa Y, Kihira Y,
Ishizawa K, Aihara K, Tsuchiya K, Tamaki T. Bilirubin exerts pro-angiogenic
property through Akt-eNOS-dependent pathway. Hypertens Res. 2015
Nov;38(11):733-40. doi: 10.1038/hr.2015.74. Epub 2015 Jul 2. PMID: 26134126.

57: Yamano N, Ikeda Y, Sakama M, Izawa-Ishizawa Y, Kihira Y, Ishizawa K,
Miyamoto L, Tomita S, Tsuchiya K, Tamaki T. A long-term high-fat diet changes
iron distribution in the body, increasing iron accumulation specifically in the
mouse spleen. J Nutr Sci Vitaminol (Tokyo). 2015;61(1):20-7. doi:
10.3177/jnsv.61.20. PMID: 25994136.

58: Kihira Y, Burentogtokh A, Itoh M, Izawa-Ishizawa Y, Ishizawa K, Ikeda Y,
Tsuchiya K, Tamaki T. Hypoxia decreases glucagon-like peptide-1 secretion from
the GLUTag cell line. Biol Pharm Bull. 2015;38(4):514-21. doi:
10.1248/bpb.b14-00612. PMID: 25832631.

59: Miyamoto L, Yagi Y, Hatano A, Kawazoe K, Ishizawa K, Minakuchi K, Tomita S,
Tsuchiya K. Spontaneously hyperactive MEK-Erk pathway mediates paradoxical
facilitation of cell proliferation in mild hypoxia. Biochim Biophys Acta. 2015
Apr;1850(4):640-6. doi: 10.1016/j.bbagen.2014.12.006. Epub 2014 Dec 10. PMID:
25497211.

60: Morimoto A, Tomita S, Imanishi M, Shioi G, Kihira Y, Izawa-Ishizawa Y,
Takaku M, Hashimoto I, Ikeda Y, Nakanishi H, Tamaki T. Overexpressed HIF-2α in
Endothelial Cells Promotes Vascularization and Improves Random Pattern Skin Flap
Survival. Plast Reconstr Surg Glob Open. 2014 May 7;2(4):e132. doi:
10.1097/GOX.0000000000000083. PMID: 25289325; PMCID: PMC4174206.

61: Tajima S, Ikeda Y, Enomoto H, Imao M, Horinouchi Y, Izawa-Ishizawa Y, Kihira
Y, Miyamoto L, Ishizawa K, Tsuchiya K, Tamaki T. Angiotensin II alters the
expression of duodenal iron transporters, hepatic hepcidin, and body iron
distribution in mice. Eur J Nutr. 2015 Aug;54(5):709-19. doi:
10.1007/s00394-014-0749-1. Epub 2014 Aug 7. PMID: 25096756.

62: Imanishi M, Ishizawa K, Sakurada T, Ishizawa Y, Yamano N, Kihira Y, Ikeda Y,
Tsuchiya K, Tamaki T. [Drug development for cardiorenal disease based on
oxidative stress control]. Yakugaku Zasshi. 2014;134(6):715-9. Japanese. doi:
10.1248/yakushi.13-00255-4. PMID: 24882646.

63: Kihira Y, Miyake M, Hirata M, Hoshina Y, Kato K, Shirakawa H, Sakaue H,
Yamano N, Izawa-Ishizawa Y, Ishizawa K, Ikeda Y, Tsuchiya K, Tamaki T, Tomita S.
Deletion of hypoxia-inducible factor-1α in adipocytes enhances glucagon-like
peptide-1 secretion and reduces adipose tissue inflammation. PLoS One. 2014 Apr
4;9(4):e93856. doi: 10.1371/journal.pone.0093856. PMID: 24705496; PMCID:
PMC3976326.

64: Imanishi M, Tomita S, Ishizawa K, Kihira Y, Ueno M, Izawa-Ishizawa Y, Ikeda
Y, Yamano N, Tsuchiya K, Tamaki T. Smooth muscle cell-specific Hif-1α deficiency
suppresses angiotensin II-induced vascular remodelling in mice. Cardiovasc Res.
2014 Jun 1;102(3):460-8. doi: 10.1093/cvr/cvu061. Epub 2014 Mar 12. PMID:
24623277.

65: Imamura Y, Tomita S, Imanishi M, Kihira Y, Ikeda Y, Ishizawa K, Tsuchiya K,
Tamaki T. HIF-2α/ARNT complex regulates hair development via induction of
p21(Waf1/Cip1) and p27(Kip1). FASEB J. 2014 Jun;28(6):2517-24. doi:
10.1096/fj.13-244079. Epub 2014 Mar 5. PMID: 24599965.

66: Ikeda Y, Ozono I, Tajima S, Imao M, Horinouchi Y, Izawa-Ishizawa Y, Kihira
Y, Miyamoto L, Ishizawa K, Tsuchiya K, Tamaki T. Iron chelation by deferoxamine
prevents renal interstitial fibrosis in mice with unilateral ureteral
obstruction. PLoS One. 2014 Feb 19;9(2):e89355. doi:
10.1371/journal.pone.0089355. PMID: 24586712; PMCID: PMC3929716.

67: Ishizawa K, Izawa-Ishizawa Y, Yamano N, Urushihara M, Sakurada T, Imanishi
M, Fujii S, Nuno A, Miyamoto L, Kihira Y, Ikeda Y, Kagami S, Kobori H, Tsuchiya
K, Tamaki T. Nitrosonifedipine ameliorates the progression of type 2 diabetic
nephropathy by exerting antioxidative effects. PLoS One. 2014 Jan
28;9(1):e86335. doi: 10.1371/journal.pone.0086335. PMID: 24489716; PMCID:
PMC3904885.

2000�ꡫ2013��

113) Shigenaga A, Ogura K, Hirakawa H, Yamamoto J, Ebisuno K, Miyamoto L, Ishizawa K, Tsuchiya K, Otaka A. Design and synthesis of hypoxia-responsive amino acid which causes prptide bond cleavage in hypoxic cells. Peptide Science 135-136, 2013.

112) Ikeda Y, Enomoto H, Tajima S, Izawa-Ishizawa Y, Kihira Y, Ishizawa K, Tomita S, Tsuchiya K, Tamaki T. Dietary iron restriction inhibits progression of diabetic nephropathy in db/db mice. Am J Physiol Renal Pathol 304, F1028-F1036, 2013.

111) Ikeda Y, Tajima S, Izawa-Ishizawa Y, Kihira Y, Ishizawa K, Yoshida S, Aihara K, Tsuchiya K, Tamaki T. Bovine milk-derived lactoferrin exerts proangiogenic effects via an Src-Akt-eNOS-dependent manner in response to ischemia. J Cardiovasc. Pharmacol. 61, 423-429, 2013.

110) Miyamoto L, Ebihara K, Kusakabe T, Aotani D, Yamamoto-Kataoka S, Sakai T, Aizawa-Abe M, Yamamoto Y, Fujikura J, Hayashi T, Hosoda K, Nakao K. Leptin Activates Hepatic 5'-AMP-activated Protein Kinase through Sympathetic Nervous System and α1-Adrenergic Receptor: A POTENTIAL MECHANISM FOR IMPROVEMENT OF FATTY LIVER IN LIPODYSTROPHY BY LEPTIN. J Biol Chem. 287, 40441-40447, 2012.

109) Shigenaga A, Ogura K, Hirakawa H, Yamamoto J, Ebisuno K, Miyamoto L, Ishizawa K, Tsuchiya K, Otaka A. Development of a reduction-responsive amino acid that induces peptide bond cleavage in hypoxic cells. Chembiochem. 13, 968-971, 2012.

108) Miyamoto L, Watanabe M, Kono M, Matsushita T, Hattori H, Ishizawa K, Nemoto H, Tsuchiya K. Cytotoxicity evaluation of symmetrically branched glycerol trimer in human hepatocellular carcinoma HepG2 cells. J Toxicol Sci. 37, 1059-1063, 2012.

107) Sakurada T, Ishizawa K, Imanishi M, Izawa-Ishizawa Y, Fujii S, Tominaga E, Tsuneishi T, Horinouchi Y, Kihira Y, Ikeda Y, Tomita S, Aihara K, Minakuchi K, Tsuchiya K, Tamaki T. Nitrosonifedipine ameliorates angiotensin II-induced vascular remodeling via antioxidative effects. Naunyn-Schmiedeberg's Arch Pharmacol, 386, 29-39, 2013.

106) Izawa-Ishizawa Y, Ishizawa K, Sakurada T, Imanishi M, Miyamoto L, Fujii S, Taira H, Kihira Y, Ikeda Y, Hamano S, Tomita S, Tsuchiya K, Tamaki T. Angiotensin II receptor blocker improves tumor necrosis factor-α-induced cytotoxicity via antioxidative effect in human glomerular endothelial cells. Pharmacology, 90, 324-331, 2012.

105) Miyamoto L, Watanabe M, Tomida Y, Kono M, Fujii S, Matsushita T, Hattori H, Ishizawa K, Nemoto H, Tsuchiya K. Acute Oral Toxicity Evaluation of Symmetrically
Branched Glycerol Trimer in ddY Mice. J Toxicol Sci. 37, 1253-1259, 2012.

104) Nemoto H, Kamiya M, Nakamoto A, Matsushita T, Matsumura K, Hattori H, Kawamura T, Taoka C, Abe S, Ishizawa K, Miyamoto L, Tsuchiya K. Synthesis of highly water-soluble fibrate derivatives via BGLation. Bioorg Med Chem Lett. 22, 6425-6428, 2012.

103) Nemoto H, Katagiri A, Kamiya M, Kawamura T, Matsushita T, Matsumura K, Itou T, Hattori H, Tamaki M, Ishizawa K, Miyamoto L, Abe S, Tsuchiya K. Synthesis of Paclitaxel-BGL Conjugates. Bioorg Med Chem. 20, 5559-5567, 2012.

102) Ikeda Y, Aihara KI, Yoshida S, Iwase T, Tajima S, Izawa-Ishizawa Y, Kihira Y, Ishizawa K, Tomita S, Tsuchiya K, Sata M, Akaike M, Kato S, Matsumoto T, Tamaki T. Heparin cofactor II, a serine protease inhibitor, promotes angiogenesis via activation of the AMPK-eNOS signaling pathway. J Biol Chem. 287, 34256-34263, 2012.

101) Ikeda Y, Tajima S, Izawa-Ishizawa Y, Kihira Y, Ishizawa K, Tomita S, Tsuchiya K, Tamaki T. Estrogen regulates hepcidin expression via GPR30-BMP6-dependent signaling in hepatocytes. PLoS One. 7, e40465, 2012.

100) Tajima S, Ikeda Y, Sawada K, Yamano N, Horinouchi Y, Kihira Y, Ishizawa K, Izawa-Ishizawa Y, Kawazoe K, Tomita S, Minakuchi K, Tsuchiya K, Tamaki T. Iron reduction by deferoxamine leads to amelioration of adiposity via the regulation of oxidative stress and obese and type 2 diabetes KKAy mice. Am.J. Physiol. Endocrinol. Metab. 302(1):E77-86, 2012.

99) KIhira Y, Yamamo N, Izawa-Ishizawa Y, Ishizawa K, Ikeda Y, Tsuchiya K, Tamaki T, Tomita S. Basic fibroblast growth factor regulates glucose metabolism throuth glucose transporter 1 induced by hypoxia-inducible factor-1α in adipocytes. Int J Biochem Cell Biol. 43,1602-11,2011.

98) Ishizawa K, Yoshizumi M, Kawai Y, Terao J, Kihira Y, Ikeda Y, Tomita S, Minakuchi K, Tsuchiya K, Tamaki T. Pharmacology in health food:metabolism of quercetin in vivo and its protective effect against arteriosclerosis. J. Pharmacol. Sci. 115, 466-470, 2011.

97) Fukuhara Y, Tsuchiya K, Horinouchi Y, Tajima S, Kihira Y, Hamano S, Kawazoe K, Ikeda Y, Ishizawa K, Tomita S, Tamaki T. Protective effect of photadegradation product of nifedipine against tumor necrosis factor alpha-induced oxidative stress in human glomerular endothelial cells. J. Med Invest. 58m, 118-126, 2011.

96) Horinouchi Y, Tsuchiya K, Taoka C, Tajima S, Kihira Y, Matsuda Y, Shishido K, Yoshida M, Hamano S, Kawazoe K, Ikeda Y, Ishizawa K, Tomita S, Tamaki T. Antioxidant effects of photodegradation product of nifedipine. Chem. Pharm. Bull. 59, 208-214, 2011.

95) Tomita S, Kihira Y, Imanishi M, Fukuhara Y, Imamura Y, Ishizawa K, Ikeda Y, Tsuchiya K, Tamaki T. Inflammatory responses of Hif-1a in T cells observed in development of vascular remodeling. J.Pharmacol. Sci. 115, 433-439, 2011.

94) Ikeda Y, Tajima S, Yoshida S, Yamano N, Kihara Y, Ishizawa K, Aihara K, Tomita S, Tsuchiya K, Tamaki T. Deferoxamine promotes angiogenesis via the activation of vascular endothlial cell function. Atheroscleosis. 215, 339-347, 2011.

93) Yanagawa H, Terao J, Takeda E, Takaishi Y, kashiwada Y, Kawazoe K, Fushitani S, Tsuchiya K, Yamauchi A, Sato C, Irahara M. Consultation clinics for complementary and alternative medicine at Japanese university hospitals:An analysis at Tokushima University Hospital Exp. Therap.Med. 1, 481-483, 2010.

92) Tajima S, Tsuchiya K, Horinouchi Y, Ishizawa K, Ikeda Y, Kihira Y, Shono M, Kawazoe K, Tomita S. and Tamaki T. Effect of angiotensin ��on iron-transporting protein expression and subsequent intracellular labile iron concentration in human glomerular endothelial cells. Hypertens Res. 33,713-721, 2010.

91) Tsuchiya K, Tomita S, Ishizawa K, Abe S, Ikeda Y, Kihira Y, Tamaki T. Dietary nitrite ameliorates renal injury in L-NAME-induced hypertensive rats. Nitric Oxide. 22, 98-103, 2010.

90) Ishizawa K., Izawa-Ishizawa Y., Dorjsuren N., Miki E., KihiraY.,Ikeda Y.,Hamano S.,Kawazoe K.,Minakuchi K.,Tomita S.,Tsuchiya K.,Tamaki T. Angiotensin II receptor blocker attenuates PDGF-induced mesangial cell migration in a receptor-independent manner. Nephrol. Dial. Transplant. 25, 364-372, 2010.

89) Kawazoe H., Takaoka K., Shibata H., Arakaki N., Higuchi T., Negayama K., Houchi H., Tsuchiya K., Takiguchi Y. Comparison of antibacterial activity of fluoroquinolones with their sucralfate-complexes against clinically-isolated bacteria. J Health Sci. 55, 790-795, 2009.

88) Ishizawa K, Dorjsuren N, Izawa-Ishizawa Y, Sugimoto R, Ikeda Y, Kihira Y, Kawazoe K, Tomita S, Tsuchiya K, Minakuchi K, Tamaki T. Inhibitory effects of adiponectin on platelet-derived growth factor-induced mesangial cell migration. J Endocrinol. 202, 309-316, 2009.

87) Motobayashi Y, Izawa-Ishizawa Y, Ishizawa K, Orino S, Yamaguchi K, Kawazoe K, Hamano S, Tsuchiya K, Tomita S, Tamaki T. Adiponectin inhibits insulin-like growth factor-1-induced cell migration by the suppression of extracellular signal-regulated kinase 1/2 activation, but not Akt in vascular smooth muscle cells. Hypertens Res. 32, 188-193, 2009.

86) Ishizawa K, Izawa-Ishizawa Y, Ohnishi S, Motobayashi Y, Kawazoe K, Hamano S, Tsuchiya K, Tomita S, Minakuchi K, Tamaki T. Drug discovery for overcoming chronic kidney disease (CKD): development of drugs on endothelial cell protection for overcoming CKD. J Pharmacol Sci. 109, 14-19, 2009.

85) Ishizawa K, Izawa-Ishizawa Y, Ohnishi S, Motobayashi Y, Kawazoe K, Hamano S, Tsuchiya K, Tomita S, Minakuchi K, Tamaki T. Quercetin glucuronide inhibits cell migration and proliferation by platelet-derived growth factor in vascular smooth muscle cells. J Pharmacol Sci. 109, 257-264, 2009.

84) Fukuzawa K., Shibata A., Okamura C., Fujiwara Y., Akai K., Tsuchiya K., Tokumura A., Bebicki J.M. Measurement of lipid hydroperoxides by the ferric-xylenol orange method: (1) Characteristics of the ferric-xylenol orange/membrane phosphatidylcholine complex. J.Nutr.Sci.Vitaminol. 55, 9-14, 2009.

83) Ohnishi H, Iwanaga S, Kawazoe K, Ishizawa K, Orino S, Tomita S, Tsuchiya K, Kanematsu Y, Harada N, Mori K, Ishikawa Y, Tamaki T. Effect of iron-quercetin complex on reduction of nitrite in vitro and in vivo systems. J Agric Food Chem.56, 10092-10098, 2008.

82) Kanematsu Y, Yamaguchi K, Ohnishi H, Motobayashi Y, Ishizawa K, Izawa Y, Kawazoe K, Kondo S, Kagami S, Tomita S, Tsuchiya K, Tamaki T. Dietary doses of nitrite restore the circulating nitric oxide level and improve renal injury in L-NAME-induced hypertensive rats. Am J Physiol Renal Physiol. 295, F1457-F1462, 2008.

81) Abe M, Takiguchi Y, Ichimaru S, Kaji S, Tsuchiya K, Wada K. Different effect of acute treatment with rosiglitazone on rat myocardial ischemia/reperfusion injury by administration method. Eur J Pharmacol. 589, 215-219, 2008.

80) Abe M, Takiguchi Y, Ichimaru S, Tsuchiya K, Wada K. Comparison of the protective effect of N-acetylcysteine by different treatments on rat myocardial ischemia-reperfusion injury. J Pharmacol Sci. 106, 571-577, 2008.

79) Izawa Y, Yoshizumi M, Ishizawa K, Fujita Y, Kondo S, Kagami S, Kawazoe K, Tsuchiya K, Tomita S, Tamaki T. Big mitogen-activated protein kinase 1 (BMK1)/extracellular signal regulated kinase 5 (ERK5) is involved in platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell migration. Hypertens Res. 30, 1107-1117, 2007.

78) Sanae Iwana, Tomoya Kawazoe, Hwan Ki Park, Koichiro Tsuchiya, Koji Ono, Kazuko Yorita, Takashi Sakai, Takenori Kusumi, Kiyoshi Fukui Chlorpromazine oligomer is a potentially active substance that inhibits human D-amino acid oxidase, product of a susceptibility gene for schizophrenia. Journal of Enzyme Inhibition and Medicinal Chemistry, 23, 901-911, 2008.

77) Nobuko Akiyama, Ikuo Nakanishi, Kei Ohkubo, Kazue Satoh, Koichiro Tsuchiya, Takeshi Nishikawa, Shunichi Fukuzumi, Nobuo Ikota, Toshihiko Ozawa, Masafumi Tsujimoto and Shunji Natori A Long-lived o-Semiquinone Radical Anion is Formed from N-?-alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine (5-S-GAD), an Insect-derived Antibacterial Substance J Biochem.142, 41-48, 2007.

76) Shinji Abe, Hideki Ohnishi, Koichiro Tsuchiya, Keisuke Ishizawa, Mayumi Torii, Yasuhisa Kanematsu, Kazuyoshi Kawazoe, Kazuo Minakuchi, Toshiaki Tamaki Calcium and Reactive Oxygen Species Mediated Zn2+-Induced Apoptosis in PC12 Cells J Pharmacol Sci. 102, 103-111, 2006.

75) Kawai Y., Kiyokawa H., Kimura Y., Kato K., Tsuchiya K., and Terao J. Hypochlorous acid-derived modification of phospholipids: characterization of aminophospholipids as regulatory molecules for lipid peroxidation Biochemistry, 45, 14201-14211, 2006.

74) Nakagawa H, Takaishi Y, Tanaka N, Tsuchiya K, Shibata H, Higuti T. Chemical constituents from the peels of Citrus sudachi. J Nat Prod. 69, 1177-1179, 2006.

73) Ali N, Yoshizumi M, Yano S, Sone S, Ohonishi H, Ishizawa K, Kanematsu Y, Tsuchiya K, Tamaki T. The Novel Src Kinase Inhibitor M475271 Inhibits VEGF-Induced Vascular Endothelial-Cadherin and beta-Catenin Phosphorylation but Increases Their Association. J Pharmacol Sci. 102, 112-120, 2006.

72) Kanematsu Y, Tsuchiya K, Ohnishi H, Motobayashi Y, Izawa Y, Ishihara M, Ishizawa K, Abe S, Kawazoe K, Tamaki T. Effects of angiotensin II type 1 receptor blockade on the systemic blood nitric oxide dynamics in Nomega-nitro-L-arginine methyl ester-treated rats. Hypertens Res. 29, 369-374, 2006.

71) Ramos FA, Takaishi Y, Shiritori M, Kawaguchi Y, Tsuchiya K, Shibata H, Higuti T, Tadokoro T, Takeuchi M. Antibacterial and antioxidant activities of quercetin oxidation products from yellow onion (Allium cepa) skin J. Agric. Food Chem. 54 (10), 3551 -3557, 2006.

70) Takiwaki H, Tsuchiya K, Fujita M, Miyaoka Y. Thioridazine induces immediate and delayed erythema in photopatch test Photochem. Photobiol. 82, 523-526, 2006.

69) Fujita Y, Yoshizumi M, Izawa Y, Ali N, Ohnishi H, Kanematsu Y, Ishizawa K, Tsuchiya K, Tamaki T. Transactivation of fetal liver kinase-1/kinase-insert domain-containing receptor by lysophosphatidylcholine induces vascular endothelial cell proliferation. Endocrinology. 147, 1377-1385, 2006.

68) Fujita Y, Izawa Y, Ali N, Kanematsu Y, Tsuchiya K, Hamano S, Tamaki T, Yoshizumi M. Pramipexole protects against H(2)O(2)-induced PC12 cell death. Naunyn Schmiedebergs Arch Pharmacol. 372, 257-266, 2006.

67) Kondo S, Shimizu M, Urushihara M, Tsuchiya K, Yoshizumi M, Tamaki T, Nishiyama A, Kawachi H, Shimizu F, Quinn MT, Lambeth DJ, Kagami S. Addition of the Antioxidant Probucol to Angiotensin II Type I Receptor Antagonist Arrests Progressive Mesangioproliferative Glomerulonephritis in the Rat. J Am Soc Nephrol. 17, 783-794, 2006.

66) Ishizawa K, Izawa Y, Ito H, Miki C, Miyata K, Fujita Y, Kanematsu Y, Tsuchiya K, Tamaki T, Nishiyama A, Yoshizumi M. Aldosterone Stimulates Vascular Smooth Muscle Cell Proliferation Via Big Mitogen-Activated Protein Kinase 1 Activation. Hypertension. 46, 1046-1052, 2005.

65) Izawa Y, Yoshizumi M, Fujita Y, Ali N, Kanematsu Y, Ishizawa K, Tsuchiya K, Obata T, Ebina Y, Tomita S, Tamaki T. ERK1/2 activation by angiotensin II inhibits insulin-induced glucose uptake in vascular smooth muscle cells. Exp Cell Res. 308, 291-299, 2005.

64) Tsuchiya K, Akai K, Tokumura A, Abe S, Tamaki T, Takiguchi Y, Fukuzawa K. Oxygen radicals photo-induced by ferric nitrilotriacetate complex. Biochim Biophys Acta. 1725, 111-119, 2005.

63) Fujita Y, Tsuchiya K, Abe S, Takiguchi Y, Kubo SI, Sakurai H. Estimation of the age of human bloodstains by electron paramagnetic resonance spectroscopy: Long-term controlled experiment on the effects of environmental factors. Forensic Sci Int. 152, 39-43, 2005.

62) Ali N, Yoshizumi M, Fujita Y, Izawa Y, Kanematsu Y, Ishizawa K, Tsuchiya K, Yano S, Sone S, Tamaki T. A Novel Src Kinase Inhibitor, M475271, Inhibits VEGF-Induced Human Umbilical Vein Endothelial Cell Proliferation and Migration. J Pharmacol Sci. 98, 130-141, 2005.

61) K. Tsuchiya, Y. Kanematsu, M. Yoshizumi, H. Ohnishi, K. Kirima, Y. Izawa, M. Shikishima, T. Ishida, S. Kondo, S. Kagami, Y. Takiguchi, Toshiaki Tamaki Nitrite is an alternative source of NO in vivo Am J Physiol Heart Circ Physiol. 288, H2163-H2170, 2005.

60) Okamoto M, Tsuchiya K, Kanematsu Y, Izawa Y, Yoshizumi M, Kagawa S, Tamaki T. Nitrite-derived nitric oxide formation following ischemia-reperfusion injury in kidney. Am J Physiol Renal Physiol. 288, F182-F187, 2005.

59) Koichiro Tsuchiya, Yoshiharu Takiguchi, Masumi Okamoto, Yuki Izawa, Yasuhisa Kanematsu, Masanori Yoshizumi, Toshiaki Tamaki Formation of systemic hemoglobin-nitric oxide complex (HbNO) from dietary nitrite J Pharmacol Sci. 96, 395-400, 2004.

58) Kaori Akai, Koichiro Tsuchiya, Akira Tokumura, Kentaro Kogure, Satoru Ueno, Akira Shibata, Toshiaki Tamaki, Kenji Fukuzawa Ability of ferric nitrilotriacetate complex with three pH-dependent conformations to induce lipid peroxidation Free Radic. Res. 38, 951-962, 2004.

57) Kyaw M, Yoshizumi M, Tsuchiya K, Izawa Y, Kanematsu Y, Fujita Y, Ali N, Ishizawa K, Yamauchi A, Tamaki T. Antioxidant Effects of Stereoisomers of N-Acetylcysteine (NAC), L-NAC and D-NAC, on Angiotensin II-Stimulated MAP Kinase Activation and Vascular Smooth Muscle Cell Proliferation. J Pharmacol Sci. 95, 483-486, 2004.

56) M.Kyaw, M.Yoshizumi, K.Tsuchiya, Y.Suzaki, Y.Kanematsu, T.Tamaki Atheroprotective effects of antioxidants through inhibition of mitogen-activated protein kinases Acta Pharmacol. Sin. 25, 977-985, 2004.

55) Suzaki Y, Yoshizumi M, Kagami S, Nishiyama A, Ozawa Y, Kyaw M, Izawa Y, Kanematsu Y, Tsuchiya K, Tamaki T. BMK1 is activated in glomeruli of diabetic rats and in mesangial cells by high glucose conditions. Kidney Int. 65, 1749-1760, 2004.

54) K. Ishizawa, M. Yoshizumi, K. Tsuchiya, H. Houchi, K. Minakuchi, S. Kagami, M. Hirose, T. Tamaki Dual effects of endothelin-1(1-31) to induce mesangial cells migration and facilitate monocyte recruitmente through MCP-1 production by mesangial cells. Hypertension Res. 27, 433-440, 2004.

53) Ali N, Yoshizumi M, Tsuchiya K, Kyaw M, Fujita Y, Izawa Y, Abe S, Kanematsu Y, Kagami S, Tamaki T. Ebselen inhibits p38 mitogen-activated protein kinase-mediated endothelial cell death by hydrogen peroxide. Eur J Pharmacol. 485, 127-135, 2004.

52) Yoshizumi M, Fujita Y, Izawa Y, Suzaki Y, Kyaw M, Ali N, Tsuchiya K, Kagami S, Yano S, Sone S, Tamaki T. Ebselen inhibits tumor necrosis factor-alpha-induced c-Jun N-terminal kinase activation and adhesion molecule expression in endothelial cells. Exp Cell Res. 292, 1-10, 2004.

51) Yoshizumi M, Fujita Y, Izawa Y, Suzaki Y, Kyaw M, Ali N, Tsuchiya K, Kagami S, Yano S, Sone S, Tamaki T. Ebselen inhibits tumor necrosis factor-alpha-induced c-Jun N-terminal kinase activation and adhesion molecule expression in endothelial cells. Exp Cell Res. 292, 1-10, 2004.

50) Yoshizumi M, Fujita Y, Izawa Y, Suzaki Y, Kyaw M, Ali N, Tsuchiya K, Kagami S, Yano S, Sone S, Tamaki T. Ebselen inhibits tumor necrosis factor-alpha-induced c-Jun N-terminal kinase activation and adhesion molecule expression in endothelial cells. Exp Cell Res. 292, 1-10, 2004.

49) Hasegawa T., Bando A., Tsuchiya K., Abe S., Okamoto M., Kirima K., Ueno S., Yoshizumi M., Houchi H., Tamaki T. Enzymatic and nonenzymatic formation of reactive oxygen species from 6-anilino-5,8-quinolinequinone Biochim. Biophys. Acta 1670, 19-27. 2004.

48) Yoshizumi M, Abe J, Tsuchiya K, Berk BC, Tamaki T. Stress and vascular responses: atheroprotective effect of laminar fluid shear stress in endothelial cells: possible role of mitogen-activated protein kinases. J Pharmacol Sci. 91, 172-176, 2003.

47) Kogure K, Tsuchiya K, Abe K, Akasu M, Tamaki T, Fukuzawa K, Terada H. Direct radical scavenging by the bisbenzylisoquinoline alkaloid cepharanthine. Biochim Biophys Acta. 1622, 1-5, 2003.

46) Tsuchiya K., Kirima K., Yoshizumi M., Tamaki T. New methods to evaluate endotherial function: Evaluation of endotherial function by hemoglobin-nitric oxide complex using electron paramagnetic resonance spectroscopy J. Pharmacol. Sci. 93, 417-422, 2003

45) K. Kirima, K. Tsuchiya, H. Sei, T. Hasegawa, M. Shikishima, Y. Motobayashi, K. Morita, M. Yoshizumi, and T. Tamaki Evaluation of systemic blood NO dynamics by EPR spectroscopy: HbNO as an endogenous index of NO Am J Physiol Heart Circ Physiol, 285, H589-H596, 2003.

Y.Ozawa, T.Hasegawa, K.Tsuchiya, M.Yoshizumi, T.Tamaki Effect of endothelin-1(1-31) on the renal resostance vessels J. Med. Invest. 50: 87-94, 2003.

44) Azuma M., Houchi H., Nishisako H., Ishizawa K., Tsuchiya K., Teraoka K., Ikehara T., Kusumi T., Minakuchi K. Inhibitory action of novel arginine derivative on catecholamine secretion evoked by acetylcholine from cultured bovine adrenal chromaffin cells J. Cardiovasc. Pharmacol. 42, S15-S18, 2003.

43) Didem DELIORMAN ORHAM, Erdem YESILADA, Fatma ERGUN, Koichiro TSUCHIYA, Yoshihisa TAKAISHI The antioxidant activity of the extracts and fractions from carduus nutans l. J. Fac. Pharm. Gazi 19, 61-66, 2002.

42) Tsuchiya K, Kirima K, Yoshizumi M, Houchi H, Tamaki T, Mason RP. The role of thiol and nitrosothiol compounds in the NO-forming reactions of the iron-MGD complex. Biochem J 367, 771-779, 2002.

41) Yoshizumi M, Kogame T, Suzaki Y, Fujita Y, Kyaw M, Kirima K, Ishizawa K, Tsuchiya K, Kagami S, Tamaki T. Ebselen attenuates oxidative stress-induced apoptosis via the inhibition of the c-Jun N-terminal kinase and activator protein-1 signalling pathway in PC12 cells. Br J Pharmacol. 136, 1023-1032, 2002.

40) Yoshizumi M, Tsuchiya K, Suzaki Y, Kirima K, Kyaw M, Moon JH, Terao J, Tamaki T. Quercetin glucuronide prevents VSMC hypertrophy by angiotensin II via the inhibition of JNK and AP-1 signaling pathway. Biochem Biophys Res Commun. 293, 1458-1465, 2002

39) Suzaki Y, Yoshizumi M, Kagami S, Koyama AH, Taketani Y, Houchi H, Tsuchiya K, Takeda E, Tamaki T. Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults J Biol Chem. 277, 9614-21, 2002.

38) K.Ishizawa, M.Yoshizumi, K.Tsuchiya, E.Takishita, Y.Nakaya, K.Kishi, Y.Ebina, H.Houchi, K.Minakuchi, T.Tamaki Effects of losartan in combination with or without exercise on insulin resistance in Otsuka Long-Evans Tokushima Fatty rats. Eur. J. Pharmacol. 430, 359-367, 2001.

37) Yoshizumi M, Tsuchiya K, Tamaki T. ]Signal transduction of reactive oxygen species and mitogen-activated protein kinases in cardiovascular disease. J Med Invest. 1-2, 11-24, 2001.

36) Yoshizumi M, Tsuchiya K, Kirima K, Kyaw M, Suzaki Y, Tamaki T. Quercetin inhibits Shc- and phosphatidylinositol 3-kinase-mediated c-Jun N-terminal kinase activation by angiotensin II in cultured rat aortic smooth muscle cells. Mol. Pharmacol. 60, 656-665, 2001.

35) T.Nakamura, H.Houchi, A.Minami, S.Sakamoto, K.Tsuchiya, Y.Niwa, K.Minakuchi, Y.Nakaya Endothelium-dependent relaxation by cilostazol, a phosphodiesteras III inhibitor, on rat throracic aorta. Life Science 69, 1709-1715, 2001.

34) Kyaw M., Yoshizumi M., Tsuchiya, K., Kirima, K., Tamaki T. Antioxidants inhibit JNK and p38 MAPK activation but not ERK ? activation by angiotensin II in rat aortic smooth muscle cells Hypertens. Res. 24, 251-261, 2001.

33) K.Kirima, K.Tsuchiya, M.Yoshizumi, T.Kameda, H.Houchi, M.Azuma, T.Tamaki Electron paramagnetic resonance study on free radical scavenging and/or generating activity of dopamine-4-O-sulfate. Chem. Pharm. Bull. 49, 576-580, 2001

32) Rusyn I, Kadiiska MB, Dikalova A, Kono H, Yin M, Tsuchiya K, Mason RP, Peters JM, Gonzalez FJ, Segal BH, Holland SM, Thurman RG. Phthalates rapidly increase production of reactive oxygen species in vivo: role of kupffer cells. Mol. Pharmacol. 59, 744-750, 2001.

31) Yesilada E., Tsuchiya K., Takaishi Y., Kawazoe K. Isolation and characterization of free radical scavenging flavonoid glycosides from the flowers of Spartium junceum by activity-guided fractionation J. Ethnopharmacology 73, 471-478, 2000

30) Naoko Okishima, Masanori Yoshizumi, Koichiro Tuchiya, .Ping Cui, Hiroko Kitamura, Toshiaki Tamaki, Hiroshi Kido. Determination of the levels of novel 31-amino acid endothelins and endothelins in human lungs. Life Science 68, 2073-2080, 2001

29) D. Inui, M. Yoshizumi, Y. Suzaki, K. Kirima, K. Tsuchiya, H. Houchi, S. Kagami, and T. Tamaki. Effect of endothelin-1(1-31) on p38 mitogen-activated protein kinase in cultured human mesangial cells. Life Science 68, 635-645, 2000.

28) Y.Ozawa, H.Houchi, K.Teraoka, M.Azuma, T.Kamimura, M.Yoshizumi, K.Tsuchiya, T.Tamaki, K.Minakuchi Long-term regulation of catecholamine formation by ouabain in cultured bovine adrenal chromaffin cells. J. Cardiovasc. Pharmacol. 36: S15-S18, 2000

27) K.Tsuchiya, M.Yoshizumi, H.Houchi, R.P.Mason Nitric oxide-forming reaction between the Iron-N-Methyl-D-glucamine Dithiocarbamate complex and nitrite. J. Biol. Chem. 275, 1551-1556, 2000.

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26) M.Yoshizumi, D.Inui, K.Kirima, K.Tsuchiya, H.Houchi, M.Azuma, H.Yasuoka, H.Kido and T.Tamaki. Comparison of the effects of endothelin-1,-2 and -3(1-31) on changes in [Ca2+]i in human coronary artery smooth muscle cells. Jpn. J. Pharmacol. 81, 298-304, 1999.

25) K.Tsuchiya, Jin-Jie Jiang, M.Yoshizumi, T.Tamaki, H.Houchi, K.Minakuchi, K. Fukuzawa, R.P. Mason. Nitric oxide-forming reactions of the water-soluble nitric oxide spin-trapping agent, MGD. Free Radic. Biol. Med. 27, 347-355, 1999

24) D.Inui, M.Yoshizumi, N.Okishima, H.Houchi, K.Tsuchiya, H.Kido, and T.Tamaki. Mechanism of endothelin-1-(1-31)-induced calcium signaling in human coronary artery smooth muscle cells. Am. J. Physiol. 276, E1067-E1072, 1999

23) Y.Ozawa, M.Yoshizumi, D.Inui, K.Tsuchiya, H.Houchi, T.Tamaki, K.Minakuchi. Plasma levels of free and sulfoconjugated catecholamines in patients with atherosclerosis. Biol. Pharm. Bull. 22, 657-659, 1999.

22) Y.Ozawa, M.Yoshizumi, Y.Fukuta, D.Inui, K.Tsuchiya, H.Houchi, T.Tamaki, K.Minakuchi Dopamine clearance during dopamine infusion in infants and children after cardiac surgery. Cardiovasc. Pharmacol. 34, S85-89, 1999.

21) M.Yoshizumi, D.Inui, K.Kirima, K.Tsuchiya, H.Houchi, M.Azuma, H.Yasuoka, ,H.Kido, T.Tamaki Comparison of the effects of endothelin-1, -2 and -3 (1-31) on changes in [Ca2+]i in human coronary artery smooth muscle cells. Jpn. J. Pharmacol. 81, 298-304, 1999.

20) K.Mori, Y.Hayabuchi, Y.Kuroda, Y.Nakaya, K.Tsuchiya, H.Moritoki Age-related endothelium-dependent vascular relaxation in rat thoracic aorta in response to colforsin. Pediatr. Int. 41, 673-81, 1999.

19) H.Houchi, M.Yoshizumi, K.Tsuchiya, M.Hirose, T.Kitagawa, T.Kujime, E.Shimizu, Y.Niwa, K.Minakuchi & T.Tamaki Endothelin-1 stimulates sodium-dependent calcium efflux from bovine adrenal chromaffin cells in culture. Br. J. Pharmacol. 125, 55-60, 1998.

18) M.Yoshizumi, S.Kim, S.Kagami, A.Hamaguchi, K.Tsuchiya, H.Houchi, H.Iwao, H.Kido, T.Tamaki. Effect of endothelin-1(1-31)on extracellular signal-regulated kinase and proliferation of human coronary artery smooth muscle cells. Br. J. Pharmacol. 124, 1019-1027, 1998.

17) M.Yoshizumi, T.Kitagawa, Y.Ozawa, K.Tano, K.Tsuchiya, H.Houchi, K.Minakuchi and T.Tamaki. Changes in plasma free and sulfoconjugated catecholamines during the perioperative period of cardiac surgery:Effect of continuous infusion of dopamine. Bio. Pharmaceut. Bull. 21, 787-791, 1998.

16) A.Tokumura, M.Okuno, K.Fukuzawa, H.Houchi, K.Tsuchiya, M.Oka Positive and negative controls by protein kinases of sodium-dependent Ca2+ efflux from cultured bovine adrenal chromaffin cells stimulated by lysophosphatidic acid. Biochim. Biophys. Acta. 1389, 67-75, 1998.

15) M. Yoshizumi, Daisuke Inui, Naoko Okishima, Hitoshi Houchi, Koichiro Tsuchiya, Hideki Wakabayashi, Hiroshi Kido, Toshiaki Tamaki. Endothelin-1(1-31), a novel vasoactive peptide, increases [Ca2+]i in human coronary artery smooth muscle cells. Eur. J. Pharamacol. 348, 305-309, 1998.

14) M. Yoshizumi, H. Houchi, K. Tsuchiya, K. Minakuchi, K. Horike, T. Kitagawa, I. Katoh, T. Tamaki. Atrial natriuretic peptide stimulates Na+-dependent Ca2+ efflux from freshly isolated adult rat cardiomyocytes. FEBS Letters 419, 255-258, 1997.

13) M. Yoshizumi, H. Houchi, Y. Ishimura, M. Hirose, T. Kitagawa, K. Tsuchiya, K. Minakuchi, T. Tamaki Effect of evodiamine on catecholamine secretion from bovine adrenal medulla. J. Med. Invest. 44, 73-78, 1997.

12) Y.Nameda, H.Miyoshi, K.Tsuchiya, Y.Nakaya, S.Arase Endotoxin-induced L-arginine pathway produces nitric oxide and modulates the Ca2+-activated K+ channel in cultured human dermal papilla cells. J Invest Dermatol. 106, 342-345, 1996.

11) K.Mori, S.Takeuchi, H.Moritoki, K.Tsuchiya, Y.Nakaya, S.Matsuoka, Y.Kuroda Endothelium-dependent relaxation of rat thoracic aorta by amrinone-induced nitric oxide release. Eur. Heart J. 17, 308-316, 1996.

10) K.Nakauchi, T.Ikata, S.Katoh, Y.Hamada, K.Tsuchiya, K.Fukuzawa Effects of lecithinized superoxide dismutase on rat spinal cord injury. J. Neurotrauma. 13, 573-582, 1996.

9) K.Tsuchiya, M.Takasugi, K.Minakuchi, K.Fukuzawa Sensitive quantitation of nitric oxide by EPR spectroscopy. Free Radic. Biol. Med. 21, 733-737, 1996.

8) Y.Hamada, T.Ikata, S.Katoh, K.Tsuchiya, M.Niwa, Y.Tsutsumishita, K.Fukuzawa Roles of nitric oxide in compression injury of rat spinal cord. Free Radic. Biol. Med. 20, 1-9, 1996.

7) H.Sakurai, M.Nakai, T.Miki, K.Tsuchiya, J.Takada, R.Matsuchita DNA cleavage by hydroxyl radicals generated in a vanadyl ion-hydrogen peroxide system. Biochem. Biophys. Res. Commun. 189, 1090-1095, 1992.

6) H.Sakurai and K.Tsuchiya A Biomimetic model for vanadium-containing bromoperoxidase. FEBS Letters 260, 109-112, 1990.

5) H.Sakurai, K.Tsuchiya, M.Nukatsuka, M.Sofue, J.Kawada Insulin-like effect of vanadyl ion on streptozotocin-induced diabetic rats. J. Endocrinol. 126, 451-459, 1990.

4) S.Kitagawa, F.Kametani, K.Tsuchiya, H.Sakurai ESR analysis with long-chain alkyl spin labels in bovine blood platelets. Relationship between the increase in membrane fluidity by alcohols and phenolic compounds and their inhibitory effects on aggregation. Biochim. Biophys. Acta. 1027, 123-129, 1990.

3) H. Sakurai and K.Tsuchiya Dating of human blood by electron spin resonance spectroscopy. Natur Wissenschaften 76, 24-25, 1989.

2) H.Sakurai, K.Tsuchiya, K.Migita An active-site model of nitrile hydratase: Axially coordinate non-heme iron complexes in the low-spin ferric state. Inorganic Chemistry 27, 3877-3879, 1988.

1) H. Sakurai and K.Tsuchiya Correlation of levels of Pt and Se in rats treated simultaneously with cisplatin and sodium selenite. Natur Wissenschaften 75, 405-406, 1988.