Tissue Regeneration

Prof.Yamamoto  Akihito E-mail:akihito@tokushima-u.ac.jp

　
Regenerative medicine using mesenchymal stem cell transplantation is expected to be highly effective in treating various intractable diseases. However, there are many difficulties in clinical application, such as low engraftment rate of transplanted cells, tumor formation, and risk of immune rejection. We are aiming to develop a new regenerative therapy by administering only therapeutic factors secreted by stem cells. We have found that serum-free culture supernatant (CM) of human dental pulp stem cells, which are considered to be neural crest-derived stem cells, contain potent tissue regenerative factors. It is becoming clear that the regulation of monocytic cell activity by stem cell CMs determines the host's ability to regenerate its own tissues. We are clarifying the reality of tissue regenerative factors produced by stem cells and developing Cell-Free Regenerative Medicine using regenerative factors that does not rely on cell transplantation. Our goal is to bring these basic medical research results to the bedside. 

 

 

 

Tissue Regeneration Professor Yamamoto Akihito
Yamamoto Akihito
Tissue Regeneration
Professor

We have been studying the tissue regeneration potential of conditioned media from deciduous dental pulp stem cells (SHED-CM). We have been the first in the world to demonstrate its remarkable regenerative ability. We are currently using SHED-CM to develop therapeutic agents for intractable diseases for which there is no cure, such as spinal cord injury. We are also aiming to apply regenerative therapy to intractable diseases in the maxillofacial area such as osteoarthritis, dry mouth, and neuropathic pain. If you are interested, please contact us anytime.

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